Edmonde Charles-Roux, who had previously worked at Elle and France-Soir, became the magazine’s editor-in-chief in 1954. Charles-Roux was a great supporter of Christian Dior's "New Look", of which she later said, "It signalled that we could laugh again - that we could be provocative again, and wear things that would grab people's attention in the street." In August 1956, the magazine issued a special ready-to-wear (prêt-à-porter) issue, signaling a shift in fashion's focus from couture production.
She left Vogue in 1966, as the result of a conflict for wanting to place a black woman on the cover of the magazine. When later asked about her departure, Charles-Roux refused to confirm or deny this account.